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Macromolecular Engineering at Interfaces

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Through our many collaborations, we have access to a variety of experimental techniques as well as in chemistry, in physical chemistry and in cell biology.

Chemists and physical chemists, we are interested in polyelectrolytes which are positively or negatively charged polymers, synthetic or of natural origin.

Based on common values of transparency and respect, our team is ambitious and successful in integrating all the skills needed to design new materials and coatings for both academic and therapeutic approaches. We want thus to develop a team where everyone’s skills are developed and where criticism is practiced.

CNRS researchers / assistant professor

Fouzia Boulmedais Loïc Jierry

Join us

If you look for a master training, a PhD or a post doc, you can contact the following people depending on your needs and your interest in organic synthesis (Loïc Jierry) or in physical chemistry (Fouzia Boulmedais)

Research areas

  • Fundamental research in polyelectrolyte complexes and multilayers

We study the buildup, the topography and the different properties of polyelectrolyte multilayers. Those films can be built with synthetic and natural polymers or functionalized by reactive funtions. Polyelectrolytes used to build a film have an influence on films topography. Ionic strenght changes induce formation of cavities in polyelectrolyte films.

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  • Responsive films towards mechanical or electrical stimulus

In recent years, numerous studies have shown the importance of mechanical properties of biological tissues in the adhesion, differentiation and cell growth. Cells probe their environment by applying mechanical forces and reaction being subject to them. The response to these forces is then transformed into chemical reaction: it is the mechano-transduction and more specifically the mechano-chemistry.

Polyelectrolytes and generally water-soluble polymers allow creating systems that respond to external stimuli. We would like in particular to develop surfaces and gels that can induce and modulate chemical reactions or specific interactions as ligand / receptor and in a reversible manner.

We also develop films that respond to an electrochemical stimuli. These films, mainly multilayer of polyelectrolytes, contain electroactive molecules. By applying a potential, these molecules are oxidized or reduced and the redox reaction is accompanied by a swelling or a deswelling of the structure.

  • Biomaterials and tissue engineering : chemistry - biology interface

Part of our research are done in collaboration with UMR 1121 INSERM, UMR 7175 CNRS and UMR CNRS 7563 and are devoted to developing coatings or polyelectrolytes based architectures for Tissue Engineering.

Development of anti-bacterial and anti-inflammatiry coatings

In the biomaterials field, one of the current issue is to avoid the bacterial infection that can induce septicemia. We develop coatings that are anti-adhesive to bacteria.

The control of the inflammation near to the implant sites is of a high interest to favor its good integration.

Development of anti-thrombotic coatings

When blood vessels with small diameter are replaced, thrombosis can be induced in the lumen of the vessel. We demonstrated that the PSS/PAH multilayers can be used as anti-thrombotic coating.

Human umbilical arteries untreated and treated with polyelectrolyte PSS/PAH multilayers coatings in the lumen.

Members of the team
Publications
Experimental technics
Collaborations